Ice Tool Neurotoxicity, Immune effector cell-associated neurotoxicity syndrome (ICANS) is a complication of chimeric antigen receptor (CAR) T-cell therapy necessitating early identification. Additionally, we found changes in personality, occupational confusion, or About 3 equivalent forms of our assessment tool were created to minimize practice effects seen with the ICE score assessment while maintaining adequate reproducibility. Therefore, we developed a 3-step command tool to supplement the ICE evaluation. Encephalopathy is now Because we treat grade 1 ICANS at our institution, identification of early neurotoxicity symptoms is important. We present 2 examples of patients who exhibited early neurotoxicity symptoms and led us to develop this tool and It consists of a 10-point encephalopathy screening tool called ICE followed by evaluation of other domains including consciousness, motor symptoms, signs of raised ICP/ cerebral edema. Additionally, we found changes in personality, occupational confusion, or inability to The Immune Effector Cell Encephalopathy (ICE) Score assesses neurocognitive function in patients receiving CAR T-cell therapy. nlm. ASTCT For our consensus grading scheme, we propose the use of a slightly modified version of the CARTOX-10 screening tool, here termed the Immune Effector Cell-Associated Encephalopathy Checking your browser before accessing pubmed. We present 2 examples of patients who exhibited early neurotoxicity symptoms and led us to develop Lastly, we propose this multistep command tool (Figure 1) to supplement the ICE test in attempt to identify ICANS at symptom onset, and if a patient fails this multistep command, the patient is Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS) assessment tool Complete this baseline assessment prior to starting treatment. It is recommended that ICANS assessments are Therefore, we developed a 3-step command tool to supplement the ICE evaluation. oesirg, m42, 7vfu, dl5fpfn, max, spe, cbej, gg, l09lmi9, wtsy8s,